New Scientific Study Reveals Genetic Causes of Miscarriage in Healthy Women

Kathmandu. Many believe that miscarriage occurs only when a woman's health is weak or due to negligence during pregnancy. But new scientific studies have shown that miscarriage can also occur in completely healthy and fit women.

Researchers have stated that a new reason for this is related to the parents' genes. In a new study published in Nature, scientists analyzed genetic data of about 140,000 IVF embryos. During the study, it was found that many embryos had an abnormal number of chromosomes. This condition is called "aneuploidy".

In simple terms, aneuploidy is having more or fewer chromosomes than normal in the body's cells. In such a condition, the embryo cannot develop properly, and pregnancy can end in the early months. According to research, about half of the miscarriages in the first and second trimesters are related to chromosomal abnormalities. This means that the embryo may have had genetic problems from the beginning, which stops its development.

Scientists have confirmed that the risk of miscarriage also increases with age. But according to them, it is not just age, but some specific genes also play an important role. In the study, a specific gene called SMC1B was identified. This gene is related to keeping the chromosomes properly attached during egg formation. If this gene changes, the chromosomes cannot separate correctly, which can cause problems in the embryo and increase the risk of miscarriage.

In addition, other genes such as C14orf39, CCNB1IP1, and RNF212 have also been shown to be related to this process. According to scientists, the process of egg formation in women begins even when they are in their mother's womb. After this, this process remains dormant for many years and then becomes active again when it is released from the ovary. The possibility of chromosomal abnormalities increases during this long interval.

However, not all miscarriages are solely due to genetic reasons. Increasing age, stress, unhealthy lifestyle, smoking, pollution, and some health problems can also increase the risk of miscarriage. According to researchers, this study can provide significant help in developing better reproductive treatment and pregnancy care systems in the future.