Study Suggests 'Forever Chemicals' May Accelerate Biological Aging in Men More Than Women

A new study indicates that exposure to PFAS, known as 'forever chemicals,' may lead to faster biological aging in men in their 50s and 60s compared to women.

PFAS, or per- and polyfluoroalkyl substances, are chemicals that persist in the environment and the human body for many years, hence their nickname 'forever chemicals.'

According to the research team led by Xiangwei Li, the rate of biological aging appears more pronounced in men compared to their chronological age.

'The association between PFAS exposure and accelerated epigenetic aging was strongest in men aged 50–65,' Li stated. He noted that this association was weaker and statistically less significant in younger men and those over 65. While some association was observed in women, it was generally smaller and less consistent compared to men, the study found.

Scientist Jane Munkel, who was not involved in the study, likened this to the sex-specific effects seen with chemicals that affect the hormone system. This system regulates key bodily functions such as growth, metabolism, mood, and reproduction. According to the research, PFAS accumulation in men could potentially lead to decreased testosterone, impaired sperm quality, and an increased risk of testicular and kidney cancer. Previous studies have suggested that women might eliminate some PFAS faster due to pregnancy, breastfeeding, and menstruation.

However, experts caution that this study should not be considered definitive proof of cause-and-effect. The American Chemistry Council, a US industry group, commented that the study is exploratory and based on a small sample size. The council stated that it does not provide concrete evidence that PFAS causes aging, but it does point to the need for further research.